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Dr Martina Callaghan
The Physics Group develops and optimizes advanced magnetic resonance imaging (MRI) methods for non-invasively characterizing the structure and function of the human brain. The developments range from novel MRI pulse sequences over image reconstruction to data processing methods, multi-modal imaging approaches and biophysical modelling of contrast mechanisms.
The developments are supported by the latest imaging hardware. The Wellcome Trust Centre for Neuroimaging is equipped with three 3T whole body MRI scanners (Siemens Tim Trio inc. 32-ch head coil), an MEG system (CTF/VSM), and MR compatible EEG and TMS systems. One of the MRI systems is equipped with an optical tracking system for ultrafast prospective motion correction.
Our main research interests comprise (see also Physics publications):
- Quantitative MRI and Voxel-Based Quantification (VBQ)
- Whole-brain B1 mapping for correction of quantitative MRI data
- High-resolution cortical myelin mapping and MRI-based in-vivo histology
- High-resolution functional MR Imaging (fMRI)
- Layer-specific functional MR imaging (fMRI)
- Reduction of susceptibility artifacts in functional MRI (fMRI)
- Physiological noise correction in fMRI
- Prospective Motion Correction
- Real-time fMRI (rtfMRI) and neurofeedback
- Development of raw data post-processing techniques for image artefact suppression
- Concurrent TMS and fMRI
- Parallel imaging and generalized image reconstruction
- Improvements in data acquisition & artefact correction for diffusion MRI
- Artefact correction in diffusion MRI (ACID) - SPM Toolbox