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MEG Team awarded funding to enhance technology aiming to improve accuracy of pre-surgical planning for epilepsy

A new project to harness quantum technology to enable better planning for patients undergoing epilepsy surgery has been funded by the UK Quantum Technology Hub in Sensors and Timing.

The Hub, which is led by the University of Birmingham, has awarded £300,000 to the project via its Partnership Resource Fund (PRF). Researchers at the University of Nottingham and University College London will carry out the research, which aims to improve the accuracy of pre-surgical planning.

The team will combine quantum-enabled wearable technology with new biophysical modelling into a helmet-style device that will enable brain activity to be measured even whilst a subject moves. This will make it possible for children and those with complex needs to have access to this technology. By measuring electric discharges during seizures, it is possible to pinpoint the location of the seizure with much greater accuracy. This information can be used to design highly targeted and completely non-invasive surgical planning.

Epilepsy is a disorder of the brain in which there is a tendency to have recurring seizures, and currently affects 600,000 people in the UK. If patients do not respond to medication – in around 30% of cases – neurosurgery is the most effective solution to remove the seizure focus. Pre-surgical planning is incredibly important to ensure that whilst the seizure focus is removed, cortical function remains intact.

Presently, this planning stage is difficult, and can depend on an additional operation to implant electrodes in the brain. Although functional neuroimaging offers a non-invasive method of pre-surgical planning, conventional systems rely on patients keeping still within large and cumbersome machines. This makes it difficult to measure brain activity, particularly whilst a patient is having a seizure.

Professor Gareth Barnes, Principal Investigator of the MEG Team at the Wellcome Centre for Human Neuroimaging, said:

“We are very excited to be part of this Quantum Technology Hub funding initiative. These new quantum sensors will considerably add to our understanding of how seizures propagate and could lead to faster, safer and more accurate planning of epilepsy surgery.”

Dr Simon Bennett, Director at the UK Quantum Technology Hub Sensors and Timing, said: “We are delighted to support such a vital project using our Partnership Resource Fund. On completion, this project has the potential to have a clear impact on surgical outcomes, which speaks volumes about the capabilities of quantum sensors.”

This project will be undertaken at the Wellcome Centre for Human Neuroimaging (WCHN) and will take advantage of the existing strong and productive links between UCL and Nottingham and the neurology team at the National Hospital for Neurology and Neurosurgery.