Huntington’s Disease (HD) is a genetic, neurodegenerative disorder that is characterised by motor, cognitive and neuropsychiatric dysfunction. We recently completed the HD-YAS study for which structural, diffusion, functional (resting state and task) and multiparametric mapping data were acquired in a group of young adults with the HD-gene.
The goal is to investigate the point at which brain changes begin to occur in HD gene-carriers; this is particularly important given the ongoing Phase 3 HD ‘gene silencing’ antisense oligonucleotide therapy trial and our understanding of the optimal time for therapeutic intervention.
- Mutant huntingtin and neurofilament light have distinct longitudinal dynamics in Huntington’s disease Science Translational Medicine
- Diffusion imaging in Huntington’s disease: comprehensive review Journal of Neurology, Neurosurgery & Psychiatry DOI: 10.1136/jnnp-2020-324377
- View all publications by the Huntington’s Disease team