Huntington’s Disease (HD) is a genetic, neurodegenerative disorder that is characterised by motor, cognitive and neuropsychiatric dysfunction. We recently completed the HD-YAS study for which structural, diffusion, functional (resting state and task) and multiparametric mapping data were acquired in a group of young adults with the HD-gene.
The goal is to investigate the point at which brain changes begin to occur in HD gene-carriers; this is particularly important given the ongoing Phase 3 HD ‘gene silencing’ antisense oligonucleotide therapy trial and our understanding of the optimal time for therapeutic intervention.
- A biological classification of Huntington’s disease: the Integrated Staging System. Lancet Neurology, 21 (7), 632-644 DOI: 10.1016/S1474-4422(22)00120-X
- Neurofilament light associated connectivity in young-adult Huntington’s disease is related to neuronal genes Brain DOI: 10.1093/brain/awac227
- View all publications by the Huntington’s Disease team