Huntington’s Disease (HD) is a genetic, neurodegenerative disorder that is characterised by motor, cognitive and neuropsychiatric dysfunction. We recently completed the HD-YAS study for which structural, diffusion, functional (resting state and task) and multiparametric mapping data were acquired in a group of young adults with the HD-gene.
The goal is to investigate the point at which brain changes begin to occur in HD gene-carriers; this is particularly important given the ongoing Phase 3 HD ‘gene silencing’ antisense oligonucleotide therapy trial and our understanding of the optimal time for therapeutic intervention.
- Tracking Huntington & apos;s Disease Progression Using Motor, Functional, Cognitive, and Imaging Markers MOVEMENT DISORDERS DOI: 10.1002/mds.28650
- Altered nuclear architecture in blood cells from Huntington’s disease patients. Neurological Sciences DOI: 10.1007/s10072-021-05289-w
- View all publications by the Huntington’s Disease team