Huntington’s Disease (HD) is a genetic, neurodegenerative disorder that is characterised by motor, cognitive and neuropsychiatric dysfunction. We recently completed the HD-YAS study for which structural, diffusion, functional (resting state and task) and multiparametric mapping data were acquired in a group of young adults with the HD-gene.
The goal is to investigate the point at which brain changes begin to occur in HD gene-carriers; this is particularly important given the ongoing Phase 3 HD ‘gene silencing’ antisense oligonucleotide therapy trial and our understanding of the optimal time for therapeutic intervention.
- Altered iron and myelin in premanifest Huntington’s Disease more than 20 years before clinical onset: Evidence from the cross-sectional HD Young Adult Study EBioMedicine, 65 DOI: 10.1016/j.ebiom.2021.103266
- Disease Onset in Huntington’s Disease: When Is the Conversion? Movement Disorders Clinical Practice DOI: 10.1002/mdc3.13148
- View all publications by the Huntington’s Disease team