Huntington's Disease
Research team
Huntington’s Disease (HD) is a genetic, neurodegenerative disorder that is characterised by motor, cognitive and neuropsychiatric dysfunction. We recently completed the HD-YAS study for which structural, diffusion, functional (resting state and task) and multiparametric mapping data were acquired in a group of young adults with the HD-gene.
The goal is to investigate the point at which brain changes begin to occur in HD gene-carriers; this is particularly important given the ongoing Phase 3 HD ‘gene silencing’ antisense oligonucleotide therapy trial and our understanding of the optimal time for therapeutic intervention.
Research areas
- Huntington’s Disease Clinical Trials Corner: November 2022. Journal of Huntington's disease DOI: 10.3233/JHD-229006
- Forecasting individual progression trajectories in Huntington disease enables more powered clinical trials Scientific Reports, 12 DOI: 10.1038/s41598-022-18848-8
- View all publications by the Huntington’s Disease team