Huntington’s Disease (HD) is a genetic, neurodegenerative disorder that is characterised by motor, cognitive and neuropsychiatric dysfunction. We recently completed the HD-YAS study for which structural, diffusion, functional (resting state and task) and multiparametric mapping data were acquired in a group of young adults with the HD-gene.
The goal is to investigate the point at which brain changes begin to occur in HD gene-carriers; this is particularly important given the ongoing Phase 3 HD ‘gene silencing’ antisense oligonucleotide therapy trial and our understanding of the optimal time for therapeutic intervention.
- Genetic topography and cortical cell loss in Huntington’s disease link development and neurodegeneration. Brain : a journal of neurology, awad275- DOI: 10.1093/brain/awad275
- Huntington’s Disease Clinical Trials Corner: July 2023 Journal of Huntington's Disease, 1-17 DOI: 10.3233/JHD-239001
- View all publications by the Huntington’s Disease team