Huntington’s Disease (HD) is a genetic, neurodegenerative disorder that is characterised by motor, cognitive and neuropsychiatric dysfunction. We recently completed the HD-YAS study for which structural, diffusion, functional (resting state and task) and multiparametric mapping data were acquired in a group of young adults with the HD-gene.
The goal is to investigate the point at which brain changes begin to occur in HD gene-carriers; this is particularly important given the ongoing Phase 3 HD ‘gene silencing’ antisense oligonucleotide therapy trial and our understanding of the optimal time for therapeutic intervention.
- Abnormal peripheral chemokine profile in Huntington’s disease. PLoS Currents DOI: 10.1371/currents.RRN1231
- Observing Huntington’s disease: the European Huntington’s Disease Network’s REGISTRY. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 82 (12), 1409-+ DOI: 10.1136/jnnp.2010.209668
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