Memory guided behaviour
Our research focuses on the mechanisms through which memories can be formed and retrieved in the service of flexible, adaptive and goaldirected behaviour. We investigate how the medial temporal lobe memory system interacts with prefrontal mechanisms of cognitive control.
We also investigate how basal forebrain, striatal and dopaminergic midbrain regions modulate this prefrontal-mediotemporal interaction by prediction errors, anticipation, motivation and reward. This line of research integrates functional imaging, electrophysiology and magnetoencephalography with genetic and structural anatomical information as well as pharmacology.
It is relevant for a better understanding of cognitive dysfunction in healthy ageing as well as a number of neurological and neuropsychiatric conditions that we are studying such as amnesia and neurodegenerative diseases.
- Genome-wide meta-analysis for Alzheimer’s disease cerebrospinal fluid biomarkers Acta Neuropathologica DOI: 10.1007/s00401-022-02454-z
- Novelty-Related fMRI Responses of Precuneus and Medial Temporal Regions in Individuals at Risk for Alzheimer Disease Neurology, 99 (8), e775-e788 DOI: 10.1212/WNL.0000000000200667
- View all publications by the Memory guided behaviour team